Finally. A successful stage 3 NASH tx.
obeticholic acid
Intercept Pharma’s drug.
Genfits- Elafibranor in 2021
Bristol Meyers Squib - pegbelfermin
NGM Biopharmaceuticals drug
Horizon Therapuetics
ALL failed…
Background
Current leading cause of liver fibrosis is Hepatitis C (a chronic viral infection). But since Gilead and others effectively cured Hep C. The future leading cause of liver fibrosis will be NASH - non-alcoholic steatohepatitis.
This is when excess fat is stored in the liver -> with time can cause liver scarring -> fibrosis-> cirrhosis and failure or cancer.
Madrigal media release looks great on the surface. I’ll have to ready the actual study to be sure.